YOU ARE HERE: PharmaXChange.info > Chemotherapy for Bacteria > Mechanism of Action of Macrolides 2 (Blocking Translation during Bacterial Protein SynthesisPreventing the Transfer of the Peptidyl tRNA from the A-site to the P-site)
Description: Animation Illustrating theMode of Action of Macrolides in Blocking Translation during Bacterial Protein Synthesis: Preventing the Transfer of the Peptidyl tRNA from the A-site to the P-site. The macrolides (erythromycin, azithromycin, clarithromycin, dirithromycin, troleandomycin, etc.) bind reversibly to the 50S subunit. They appear to inhibit elongation of the protein by preventing the enzyme peptidyltransferase from forming peptide bonds between the amino acids. They may also prevent the transfer of the peptidyl tRNA from the A-site to the P-site as shown here.
Mode of Action of Macrolides in Blocking Translation during Bacterial Protein Synthesis: Preventing the Transfer of the Peptidyl tRNA from the A-site to the P-site. The macrolides (erythromycin, azithromycin, clarithromycin, dirithromycin, troleandomycin, etc.) bind reversibly to the 50S subunit. They appear to inhibit elongation of the protein by preventing the enzyme peptidyltransferase from forming peptide bonds between the amino acids. They may also prevent the transfer of the peptidyl tRNA from the A-site to the P-site as shown here.
