Description: Animation Illustrating the Mode of Action of Macrolides in Blocking Translation during Bacterial Protein Synthesis: Blocking Peptidyltransferase.
The macrolides (erythromycin, azithromycin, clarithromycin, dirithromycin, troleandomycin, etc.) bind reversibly to the 50S subunit.They can inhibit elongation of the protein by the peptidyltransferase, the enzyme that forms peptide bonds between the amino acids.

Mode of Action of Macrolides in Blocking Translation during Bacterial Protein Synthesis: Blocking Peptidyltransferase.
The macrolides (erythromycin, azithromycin, clarithromycin, dirithromycin, troleandomycin, etc.) bind reversibly to the 50S subunit.They can inhibit elongation of the protein by the peptidyltransferase, the enzyme that forms peptide bonds between the amino acids.