Description: Animation showing the Mechanism of Action of Aminoglycosides 1 (Aminoglycosides interfering with the translocation of tRNA from the A-Site to the P-Site).
The aminoglycosides (streptomycin, neomycin, netilmicin, tobramycin, gentamicin, amikacin, etc.) bind irreversibly to the 30S subunit of bacterial ribosomes. There is evidence that some prevent the transfer of the peptidyl tRNA from the A-site to the P-site, thus preventing the elongation of the polypeptide chain.

(Aminoglycosides interfering with the translocation of tRNA from the A-Site to the P-Site).
The aminoglycosides (streptomycin, neomycin, netilmicin, tobramycin, gentamicin, amikacin, etc.) bind irreversibly to the 30S subunit of bacterial ribosomes. There is evidence that some prevent the transfer of the peptidyl tRNA from the A-site to the P-site, thus preventing the elongation of the polypeptide chain.